{"entities":{"Q101380":{"pageid":91773,"ns":120,"title":"Item:Q101380","lastrevid":579856,"modified":"2026-08-16T18:11:02Z","type":"item","id":"Q101380","labels":{"mul":{"language":"mul","value":"ID_844053282"},"pt-br":{"language":"pt-br","value":"Distrofia miot\u00f4nica de in\u00edcio juvenil a adulto"},"en":{"language":"en","value":"Juvenile to adult onset myotonic dystrophy"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A distrofia miot\u00f4nica (DM) de in\u00edcio juvenil a adulto \u00e9 um dist\u00farbio muscular heredit\u00e1rio. Na forma juvenil, os sintomas aparecem entre o nascimento e a adolesc\u00eancia, enquanto na forma adulta o in\u00edcio ocorre em indiv\u00edduos com idade entre 20 e 40 anos. As manifesta\u00e7\u00f5es cl\u00ednicas t\u00edpicas incluem fraqueza facial, ptose das p\u00e1lpebras, perda de massa muscular nos antebra\u00e7os e panturrilhas, dificuldade em relaxar a preens\u00e3o e defeitos de condu\u00e7\u00e3o card\u00edaca. O DM tamb\u00e9m causa constipa\u00e7\u00e3o, catarata, degenera\u00e7\u00e3o retinal, baixo QI, calv\u00edcie frontal precoce, atrofia testicular, diabetes e apn\u00e9ia do sono. Defici\u00eancias graves geralmente n\u00e3o aparecem at\u00e9 cerca de 20 anos ap\u00f3s o in\u00edcio dos sintomas, e a maioria dos pacientes mant\u00e9m a capacidade de andar."},"en":{"language":"en","value":"Juvenile to adult onset myotonic dystrophy (DM) is an inherited muscular disorder. In the juvenile form symptoms appear between birth and adolescence, whereas in the adult form the onset is in individuals aged 20-40. Typical clinical manifestations include facial weakness, eyelids ptosis, muscle wasting in the forearms and calves, difficulty relaxing the grasp, and cardiac conduction defects. DM also causes constipation, cataracts, retinal degeneration, low IQ, early frontal balding, testicular atrophy, diabetes, and sleep apnoea. Severe disabilities do not usually set in until about 20 years after symptoms begin, and most patients maintain the ability to walk."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"50947007d2c14a1e6ff28cd385d7719a57b90891","datavalue":{"value":"https://id.who.int/icd/entity/844053282","type":"string"},"datatype":"url"},"type":"statement","id":"Q101380$D883BC4A-A346-463A-9981-F83DC2430481","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"ab25ad62bb6943c68d1d468eefe9524667f8a34c","datavalue":{"value":"CID11:ID_844053282","type":"string"},"datatype":"string"},"type":"statement","id":"Q101380$4D029F6F-9B14-45DB-A983-291261FB6A2F","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"879e1c48173f0bab02e2a826d1a909f18ddd5f59","datavalue":{"value":"dki-india-ID_844053282","type":"string"},"datatype":"string"},"type":"statement","id":"Q101380$6D53E5C6-1CC1-4E4D-83A5-499218094C46","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q101380$AB1118AB-3A7F-41DD-90D0-E8E9F7EBA083","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q101380$782FAB74-AE1C-4E0C-81DF-F6EF7D9220A0","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"378ac503ed43f21e1f461d2823a6ad59da580514","datavalue":{"value":{"time":"+2026-08-15T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q101380$3A47E952-084B-4C01-8E37-A66970A91199","rank":"normal"}]},"sitelinks":{}}}}