{"entities":{"Q101030":{"pageid":91423,"ns":120,"title":"Item:Q101030","lastrevid":577312,"modified":"2026-08-16T17:49:11Z","type":"item","id":"Q101030","labels":{"mul":{"language":"mul","value":"ID_1056540115"},"pt-br":{"language":"pt-br","value":"Necrose neuronal por radia\u00e7\u00e3o tardia"},"en":{"language":"en","value":"Late delayed radiation neuronal necrosis"}},"descriptions":{"pt-br":{"language":"pt-br","value":"As mudan\u00e7as patol\u00f3gicas que ocorrem v\u00e1rios meses a anos ap\u00f3s a irradia\u00e7\u00e3o craniana terap\u00eautica. A incid\u00eancia est\u00e1 relacionada \u00e0 dose total de radia\u00e7\u00e3o e se a quimioterapia concomitante foi usada. As caracter\u00edsticas cl\u00ednicas incluem comprometimento cognitivo, dem\u00eancia, transtorno da marcha, disfun\u00e7\u00e3o hipotal\u00e2mica resultando em dist\u00farbios end\u00f3crinos, neuropatia \u00f3ptica e outras neuropatias cranianas e doen\u00e7as vasculares. A diferencia\u00e7\u00e3o do tumor pode ser dif\u00edcil com a neuroimagem convencional. Uma bi\u00f3psia cerebral pode demonstrar tecido necr\u00f3tico extenso sem predom\u00ednio de c\u00e9lulas malignas. Tamb\u00e9m ocorre perda de oligodendr\u00f3citos e desmieliniza\u00e7\u00e3o."},"en":{"language":"en","value":"The pathological changes that occur several months to years following therapeutic cranial irradiation. The incidence is related to the total radiation dose and whether concurrent chemotherapy was used. Clinical features include cognitive impairment, dementia, gait disturbance, hypothalamic dysfunction resulting in endocrine disturbances, optic neuropathy and other cranial neuropathies and vascular disease. Differentiation from tumour can be difficult with conventional neuroimaging. A brain biopsy may demonstrate extensive necrotic tissue without a predominance of malignant cells. There is also loss of oligodendrocytes and demyelination."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"1438c77f7e4fa963edb45ec65a6fee1b6e4f901b","datavalue":{"value":"https://id.who.int/icd/entity/1056540115","type":"string"},"datatype":"url"},"type":"statement","id":"Q101030$2CE6E355-CC0F-46F8-AB1A-5DC80A5D1383","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"d61a6f051314bb3fa05f5402b2ed8b1df94ac026","datavalue":{"value":"CID11:ID_1056540115","type":"string"},"datatype":"string"},"type":"statement","id":"Q101030$9E81900C-C3C4-4F4A-9F97-7D80420D02BF","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"a14c2fa11b4a1b0d4a04b3fd78293a8b53851ccb","datavalue":{"value":"dki-india-ID_1056540115","type":"string"},"datatype":"string"},"type":"statement","id":"Q101030$DC9B6236-2645-4534-A6A8-019709E66B81","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q101030$253B0801-AC2A-4D69-B287-852B2F692031","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q101030$8613A1A2-9901-4AA7-AF41-C9AD3CFF67CB","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"378ac503ed43f21e1f461d2823a6ad59da580514","datavalue":{"value":{"time":"+2026-08-15T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q101030$7544092F-614C-43A5-89E7-0F58137E6212","rank":"normal"}]},"sitelinks":{}}}}