{"entities":{"Q100579":{"pageid":90972,"ns":120,"title":"Item:Q100579","lastrevid":574001,"modified":"2026-08-16T17:18:15Z","type":"item","id":"Q100579","labels":{"mul":{"language":"mul","value":"ID_1483064286"},"pt-br":{"language":"pt-br","value":"Encefalite paraneopl\u00e1sica do tronco encef\u00e1lico, autoanticorpo neuronal positivo"},"en":{"language":"en","value":"Paraneoplastic brainstem encephalitis, neural autoantibody positive"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Encefalite paraneopl\u00e1sica de tronco cerebral soropositiva para autoanticorpos neurais. Quando esses anticorpos neurais t\u00eam como alvo ant\u00edgenos da membrana plasm\u00e1tica, eles s\u00e3o efetores de les\u00e3o (por exemplo, autoanticorpos complexos de canais de pot\u00e1ssio controlados por voltagem) por meio de m\u00faltiplos mecanismos efetores. No entanto, quando almejando ant\u00edgenos nucleares ou citoplasm\u00e1ticos (por exemplo, anticorpo nuclear antineuronal tipo 2 [ANNA-2 ou anti-Ri] associado a c\u00e2nceres de pulm\u00e3o e de mama), eles s\u00e3o marcadores de uma les\u00e3o mediada por c\u00e9lulas T efetoras, pois s\u00e3o inacess\u00edveis ao ataque imunol\u00f3gico em situ, mas os pept\u00eddeos de prote\u00ednas intracelulares s\u00e3o exibidos em mol\u00e9culas de MHC de classe 1 reguladas positivamente em um meio de citocinas pr\u00f3-inflamat\u00f3rias e, em seguida, acess\u00edveis a c\u00e9lulas T citot\u00f3xicas espec\u00edficas de pept\u00eddeo._x000D_ _x000D_ Os autoanticorpos neurais associados incluem:_x000D_ _x000D_ AMPA-R (anticorpos do receptor do \u00e1cido amino-3-hidroxi-5-metil-4-isoxazolpropi\u00f4nico); anfifisina; ANNA-1 (anti-Hu) (auto-anticorpo nuclear antineuronal tipo 1); ANNA-2 (anti-Ri) (autoanticorpo nuclear antineuronal tipo 2); ANNA-3 (auto-anticorpo nuclear antineuronal tipo 3); CRMP5 (anti-CV2) (prote\u00edna 5 do mediador da resposta da colapsina); GABABR (autoanticorpos de \u00e1cido gama-aminobut\u00edrico tipo A); Ma1; Ma2;"},"en":{"language":"en","value":"Paraneoplastic brainstem encephalitis seropositive for neural autoantibodies. When these neural antibodies target plasma membrane antigens they are effectors of injury (e.g. voltage gated potassium channel complex autoantibodies) through multiple effector mechanisms. However, when targeting nuclear or cytoplasmic antigens (e.g. antineuronal nuclear antibody type 2 [ANNA-2 or anti-Ri] associated with lung and breast cancers) they are markers of a T-cell effector mediated injury as they are inaccessible to immune attack in situ, but peptides from intracellular proteins are displayed on upregulated MHC class 1 molecules in a pro-inflammatory cytokine milieu and then accessible to peptide specific cytotoxic T-cells.  Associated neural autoantibodies include: AMPA-R (amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antibodies); amphiphysin; ANNA-1(anti-Hu) (antineuronal nuclear autoantibody type 1); ANNA-2(anti-Ri) (antineuronal nuclear autoantibody type 2); ANNA-3 (antineuronal nuclear autoantibody type 3); CRMP5(anti-CV2) (collapsin response mediator protein 5); GABABR (Gamma-aminobutyric-acid type-A autoantibodies); Ma1; Ma2;"}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"265bdb8eab5f20cd9632c7bb27053dd6686df37d","datavalue":{"value":"https://id.who.int/icd/entity/1483064286","type":"string"},"datatype":"url"},"type":"statement","id":"Q100579$AAA57A1B-8A68-40FA-B4FF-8F782AA8CEE6","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"dad8f7af486fba7b0bd20bce240d654790d6fd86","datavalue":{"value":"CID11:ID_1483064286","type":"string"},"datatype":"string"},"type":"statement","id":"Q100579$C71A1997-FF80-43C3-A8F6-302351BA770A","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"14615bc5fbcb3c8f3eee554029711e579f11fbc4","datavalue":{"value":"dki-india-ID_1483064286","type":"string"},"datatype":"string"},"type":"statement","id":"Q100579$1BC8EECF-1990-4205-9942-63B2CE9DD9F8","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q100579$70652555-71F6-4E77-B54A-AF4DCC9EEC37","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q100579$B33DEB4F-78E1-4383-8252-DA4707185201","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"378ac503ed43f21e1f461d2823a6ad59da580514","datavalue":{"value":{"time":"+2026-08-15T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q100579$84423E32-1F21-4678-9B40-67513A94284D","rank":"normal"}]},"sitelinks":{}}}}